Virological Outcomes of Second-line Protease Inhibitor–Based Treatment for Human Immunodeficiency Virus Type 1 in a High-Prevalence Rural South African Setting: A Competing-Risks Prospective Cohort Analysis
Identifieur interne : 000030 ( Main/Exploration ); précédent : 000029; suivant : 000031Virological Outcomes of Second-line Protease Inhibitor–Based Treatment for Human Immunodeficiency Virus Type 1 in a High-Prevalence Rural South African Setting: A Competing-Risks Prospective Cohort Analysis
Auteurs : Dami Collier [Royaume-Uni] ; Collins Iwuji [Afrique du Sud, Royaume-Uni] ; Anne Derache [Afrique du Sud, France] ; Tulio De Oliveira [Afrique du Sud] ; Nonhlanhla Okesola [Afrique du Sud] ; Alexandra Calmy [Suisse] ; Francois Dabis [France] ; Deenan Pillay [Royaume-Uni, Afrique du Sud] ; Ravindra K. Gupta [Royaume-Uni, Afrique du Sud]Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Agents antiVIH (usage thérapeutique), Charge virale, Femelle, Génotype, Humains, Infections à VIH (), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Infections à VIH (épidémiologie), Inhibiteurs de protéase du VIH (usage thérapeutique), Jeune adulte, Mâle, Population rurale, Prévalence, République d'Afrique du Sud (épidémiologie), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tuberculose (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Études prospectives.
- MESH :
- génétique : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH, Inhibiteurs de protéase du VIH.
- virologie : Infections à VIH.
- épidémiologie : Infections à VIH, République d'Afrique du Sud.
- Adolescent, Adulte, Adulte d'âge moyen, Charge virale, Femelle, Génotype, Humains, Infections à VIH, Jeune adulte, Mâle, Population rurale, Prévalence, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Tuberculose, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études prospectives.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-HIV Agents (therapeutic use), Female, Genotype, HIV Infections (complications), HIV Infections (drug therapy), HIV Infections (epidemiology), HIV Infections (virology), HIV Protease Inhibitors (therapeutic use), HIV-1 (classification), HIV-1 (genetics), HIV-1 (isolation & purification), Humans, Male, Middle Aged, Prevalence, Prospective Studies, Rural Population, South Africa (epidemiology), Treatment Outcome, Tuberculosis (complications), Viral Load, Young Adult.
- MESH :
- chemical , therapeutic use : Anti-HIV Agents, HIV Protease Inhibitors.
- classification : HIV-1.
- complications : HIV Infections, Tuberculosis.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections, South Africa.
- genetics : HIV-1.
- isolation & purification : HIV-1.
- virology : HIV Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Rural Population, Treatment Outcome, Viral Load, Young Adult.
Abstract
A community based, second-line treatment cohort of 102 subjects was followed monthly in community clinics with a total of 178 patient-years of follow-up; second-line virological failure was frequent in this setting.
Url:
DOI: 10.1093/cid/cix015
PubMed: 28329393
PubMed Central: 5439490
Affiliations:
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country strict</wicri:regionArea></affiliation></author><author><name sortKey="Iwuji, Collins" sort="Iwuji, Collins" uniqKey="Iwuji C" first="Collins" last="Iwuji">Collins Iwuji</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Africa Health Research Institute</institution>,<addr-line>Durban, KwaZulu-Natal</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Research Department of Infection and Population Health, University College</institution><addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Derache, Anne" sort="Derache, Anne" uniqKey="Derache A" first="Anne" last="Derache">Anne Derache</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Africa Health Research Institute</institution>,<addr-line>Durban, KwaZulu-Natal</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004"><institution>Sorbonne Universités, University Pierre and Marie Curie Université Paris 06, Inserm, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136)</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="De Oliveira, Tulio" sort="De Oliveira, Tulio" uniqKey="De Oliveira T" first="Tulio" last="De Oliveira">Tulio De Oliveira</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Africa Health Research Institute</institution>,<addr-line>Durban, KwaZulu-Natal</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0005"><institution>University of KwaZulu-Natal</institution>,<addr-line>Durban</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Okesola, Nonhlanhla" sort="Okesola, Nonhlanhla" uniqKey="Okesola N" first="Nonhlanhla" last="Okesola">Nonhlanhla Okesola</name><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Africa Health Research Institute</institution>,<addr-line>Durban, KwaZulu-Natal</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Calmy, Alexandra" sort="Calmy, Alexandra" uniqKey="Calmy A" first="Alexandra" last="Calmy">Alexandra Calmy</name><affiliation wicri:level="1"><nlm:aff id="AF0006"><institution>Geneva University Hospital, HIV Unit, Department of Internal Medicine</institution>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation wicri:level="1"><nlm:aff id="AF0007"><institution>INSERM U1219—Centre Inserm Bordeaux Population Health, Université de Bordeaux</institution>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0008"><institution>Université de Bordeaux, ISPED, Centre INSERM U1219-Bordeaux Population Health</institution>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pillay, Deenan" sort="Pillay, Deenan" uniqKey="Pillay D" first="Deenan" last="Pillay">Deenan Pillay</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Infection and Immunity, University College</institution><addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Africa Health Research Institute</institution>,<addr-line>Durban, KwaZulu-Natal</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gupta, Ravindra K" sort="Gupta, Ravindra K" uniqKey="Gupta R" first="Ravindra K." last="Gupta">Ravindra K. Gupta</name><affiliation wicri:level="1"><nlm:aff id="AF0001"><institution>Department of Infection and Immunity, University College</institution><addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0002"><institution>Africa Health Research Institute</institution>,<addr-line>Durban, KwaZulu-Natal</addr-line>,<country>South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Anti-HIV Agents (therapeutic use)</term><term>Female</term><term>Genotype</term><term>HIV Infections (complications)</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (epidemiology)</term><term>HIV Infections (virology)</term><term>HIV Protease Inhibitors (therapeutic use)</term><term>HIV-1 (classification)</term><term>HIV-1 (genetics)</term><term>HIV-1 (isolation & purification)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Prospective Studies</term><term>Rural Population</term><term>South Africa (epidemiology)</term><term>Treatment Outcome</term><term>Tuberculosis (complications)</term><term>Viral Load</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (usage thérapeutique)</term><term>Charge virale</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Infections à VIH ()</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (virologie)</term><term>Infections à VIH (épidémiologie)</term><term>Inhibiteurs de protéase du VIH (usage thérapeutique)</term><term>Jeune adulte</term><term>Mâle</term><term>Population rurale</term><term>Prévalence</term><term>République d'Afrique du Sud (épidémiologie)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tuberculose ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term><term>HIV Protease Inhibitors</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term><term>Inhibiteurs de protéase du VIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à VIH</term><term>République d'Afrique du Sud</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Prospective Studies</term><term>Rural Population</term><term>Treatment Outcome</term><term>Viral Load</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Infections à VIH</term><term>Jeune adulte</term><term>Mâle</term><term>Population rurale</term><term>Prévalence</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tuberculose</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>A community based, second-line treatment cohort of 102 subjects was followed monthly in community clinics with a total of 178 patient-years of follow-up; second-line virological failure was frequent in this setting.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Boender, Ts" uniqKey="Boender T">TS Boender</name></author><author><name sortKey="Sigaloff, Kc" uniqKey="Sigaloff K">KC Sigaloff</name></author><author><name sortKey="Mcmahon, Jh" uniqKey="Mcmahon J">JH McMahon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, Rk" uniqKey="Gupta R">RK Gupta</name></author><author><name sortKey="Hill, A" uniqKey="Hill A">A Hill</name></author><author><name sortKey="Sawyer, Aw" uniqKey="Sawyer A">AW Sawyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamers, Rl" uniqKey="Hamers R">RL Hamers</name></author><author><name sortKey="Sigaloff, Kc" uniqKey="Sigaloff K">KC Sigaloff</name></author><author><name sortKey="Wensing, Am" uniqKey="Wensing A">AM 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Gupta</name><name sortKey="Iwuji, Collins" sort="Iwuji, Collins" uniqKey="Iwuji C" first="Collins" last="Iwuji">Collins Iwuji</name><name sortKey="Pillay, Deenan" sort="Pillay, Deenan" uniqKey="Pillay D" first="Deenan" last="Pillay">Deenan Pillay</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Iwuji, Collins" sort="Iwuji, Collins" uniqKey="Iwuji C" first="Collins" last="Iwuji">Collins Iwuji</name></noRegion><name sortKey="De Oliveira, Tulio" sort="De Oliveira, Tulio" uniqKey="De Oliveira T" first="Tulio" last="De Oliveira">Tulio De Oliveira</name><name sortKey="De Oliveira, Tulio" sort="De Oliveira, Tulio" uniqKey="De Oliveira T" first="Tulio" last="De Oliveira">Tulio De Oliveira</name><name sortKey="Derache, Anne" sort="Derache, Anne" uniqKey="Derache A" first="Anne" last="Derache">Anne Derache</name><name sortKey="Gupta, Ravindra K" sort="Gupta, Ravindra K" uniqKey="Gupta R" first="Ravindra K." last="Gupta">Ravindra K. Gupta</name><name sortKey="Okesola, Nonhlanhla" sort="Okesola, Nonhlanhla" uniqKey="Okesola N" first="Nonhlanhla" last="Okesola">Nonhlanhla Okesola</name><name sortKey="Pillay, Deenan" sort="Pillay, Deenan" uniqKey="Pillay D" first="Deenan" last="Pillay">Deenan Pillay</name></country><country name="France"><noRegion><name sortKey="Derache, Anne" sort="Derache, Anne" uniqKey="Derache A" first="Anne" last="Derache">Anne Derache</name></noRegion><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name></country><country name="Suisse"><noRegion><name sortKey="Calmy, Alexandra" sort="Calmy, Alexandra" uniqKey="Calmy A" first="Alexandra" last="Calmy">Alexandra Calmy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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